- Product Name
- CasNo
- MF
- MW
- Content
- Appearance
- Packing
- Apply
- Lenvatinib mesylate
- 857890-39-2
- C21H19ClN4O4.CH4O3S
- 522.966
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Quality products make an important contribution to long-term revenue and profitability. Manufacturer supply top purity Lenvatinib mesylate 857890-39-2 with GMP standards
Lenvatinib Mesylate is used in preparation of anti-human CTLA4xPD-1 bispecific antibodies for diagnosis, prevention and treatment of tumor or anemia.
methanesulfonic acid
![1-{2-chloro-4-[(6-cyano-7-methoxy-quinolin-4-yl)oxy]phenyl}-3-cyclopropylurea](/upload/2024/12/dd07fe0c-8e26-4df3-9027-90aa5d596148.png)
1-{2-chloro-4-[(6-cyano-7-methoxy-quinolin-4-yl)oxy]phenyl}-3-cyclopropylurea
![4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinoline-carboxamide methanesulfonate](/upload/2024/12/afaa64e9-1bf0-4dca-8e30-aff9c8e35c78.png)
4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinoline-carboxamide methanesulfonate
| Conditions | Yield |
|---|---|
|
In
ethanol; water;
at 20 ℃;
Solvent;
Temperature;
Industrial scale;
|
92% |
lenvatinib
methanesulfonic acid
4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinoline-carboxamide methanesulfonate
| Conditions | Yield |
|---|---|
|
In
tetrahydrofuran; water;
at 20 ℃;
for 3.66667h;
|
99% |
|
In
ethanol;
at 15 - 25 ℃;
for 3h;
Solvent;
Time;
|
95.8% |
|
With
acetic acid;
at 20 - 35 ℃;
|
94% |
|
In
methanol;
at 20 ℃;
|
92.9% |
|
In
N,N-dimethyl acetamide;
at 25 - 65 ℃;
|
86.5% |
|
In
isopropyl alcohol;
at 80 - 85 ℃;
|
82% |
|
In
methanol;
at 20 - 75 ℃;
for 22h;
Inert atmosphere;
|
74.5% |
|
In
methanol;
at 20 - 70 ℃;
for 24h;
Product distribution / selectivity;
|
|
|
lenvatinib; methanesulfonic acid;
In
acetic acid; isopropyl alcohol;
at 40 ℃;
for 0.333333h;
In
Isopropyl acetate; acetic acid; isopropyl alcohol;
at 15 - 40 ℃;
for 16h;
Product distribution / selectivity;
|
|
|
lenvatinib; methanesulfonic acid;
In
acetic acid;
at 20 - 70 ℃;
for 24h;
In
ethanol; acetic acid;
at 20 - 40 ℃;
for 12h;
Product distribution / selectivity;
|
|
|
In
acetic acid; isopropyl alcohol;
at 17.6 - 30 ℃;
for 1.4h;
Product distribution / selectivity;
|
|
|
In
methanol;
at 20 - 70 ℃;
for 14h;
Product distribution / selectivity;
|
|
|
With
acetic acid;
In
ethyl acetate;
at 20 - 50 ℃;
for 10h;
|
|
|
With
acetic acid;
In
propan-1-ol; Isopropyl acetate;
at 25 - 40 ℃;
for 2.66667h;
|
|
|
With
acetic acid;
In
dimethyl sulfoxide; ethyl acetate;
at 20 - 80 ℃;
for 20h;
Product distribution / selectivity;
|
|
|
With
acetic acid;
In
Isopropyl acetate; isopropyl alcohol;
at 15 - 40 ℃;
for 16.3333h;
Product distribution / selectivity;
|
|
|
With
acetic acid;
In
isopropyl alcohol;
at 20 - 30 ℃;
for 1.4h;
Product distribution / selectivity;
|
|
|
With
acetic acid;
In
ethanol;
at 20 - 50 ℃;
for 12h;
Product distribution / selectivity;
|
|
|
lenvatinib; methanesulfonic acid;
In
acetic acid; isopropyl alcohol;
at 40 ℃;
for 0.333333h;
In
Isopropyl acetate; acetic acid; isopropyl alcohol;
at 15 ℃;
for 16h;
Product distribution / selectivity;
|
|
|
lenvatinib; methanesulfonic acid;
In
acetic acid; isopropyl alcohol;
at 17.6 - 30 ℃;
for 1.4h;
In
ethanol;
at 20 ℃;
for 1h;
Product distribution / selectivity;
|
|
|
In
dimethyl sulfoxide; isopropyl alcohol;
at 15 - 62 ℃;
for 3 - 3.5h;
Product distribution / selectivity;
|
|
|
In
ethanol; acetic acid;
at 20 - 50 ℃;
for 12h;
Product distribution / selectivity;
|
|
|
In
methanol;
at 20 - 70 ℃;
for 24h;
Product distribution / selectivity;
|
|
|
In
isopropyl alcohol;
at 60 - 65 ℃;
for 5h;
|
1.1 g |
|
In
acetonitrile;
at 20 ℃;
for 24h;
|
|
|
at 25 - 30 ℃;
for 24h;
|
|
|
With
acetic acid;
at 20 - 30 ℃;
for 0.5h;
|
10.3 g |
|
With
acetic acid;
In
propan-1-ol;
at 25 - 30 ℃;
for 0.333333h;
Solvent;
Temperature;
Reagent/catalyst;
|
1.8 g |
|
In
isopropyl alcohol;
at 40 ℃;
for 1h;
Temperature;
Solvent;
|
1.12 g |
|
In
acetonitrile;
at 20 ℃;
for 24h;
Solvent;
Temperature;
|
The CAS number of lenvatinib Mesylate is 857890-39-2.
More information of lenvatinib Mesylate 857890-39-2 are:
|
CAS Number |
857890-39-2 |
|
PSA |
178.32000 |
|
LogP |
5.82090 |
Synonyms for lenvatinib Mesylate 857890-39-2:6-Quinolinecarboxamide,4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-,monomethanesulfonate
The chemical formula of lenvatinib Mesylate is C21H19ClN4O4.CH4O3S which containing 22 Carbon atoms,23 Hydrogen atoms,1 Chlorine atoms,4 Nitrogen atoms,4 Oxygen atoms and 1 Sulfur atoms,and the molecular weight of lenvatinib Mesylate is 522.966.
Lenvatinib mesylate (lenvatinib) is an orally available, receptor‐type tyrosine kinase inhibitor, which was developed at Eisai in 2015. It was approved by the FDA in 2015 for the treatment of differentiated thyroid cancer that is either locally recurrent, metastatic, or progressive and did not respond to radioactive iodine treatment. In May 2016, the FDA approved the drug as a combination therapy with everolimus for the treatment of advanced renal cell carcinoma. Because VEGF (and fibroblast growth factor receptors, known as FGFRs) are thought to play a role in cardiovascular signaling pathways, VEGF2R and FGFR inhibition are thought to be the mechanisms behind the primary side effect of lenvatinib mesylate, which is hypertension.
Relevant articles related to lenvatinib Mesylate:
|
Article |
Source |
|
Synthesis method of lenvatinib and new intermediate |
- Paragraph 0049; 0062-0064, (2020/07/24) |
|
Method for refining Lenvatinib mesylate |
- Paragraph 0033-0039, (2020/03/02) |
Hubei Mawer Biological Technology Co., Ltd. is a quality supplier of lenvatinib Mesylate. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on lenvatinib Mesylate 857890-39-2.