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Crizotinib

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  • Crizotinib
  • 877399-52-5
  • C<sub>21</sub>H<sub>22</sub>Cl<sub>2</sub>FN<sub>5</sub>O
  • 450.343
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What is the Crizotinib ?

Crizotinib is , while it's Molecular Formula is C21H22Cl2FN5O. Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. In August 2011, the United States FDA approved crizotinib for the treatment of anaplastic lymphoma kinase (ALK) rearranged non-small-cell lung cancer (NSCLC).

What is the CAS number for Crizotinib ?

The CAS number of Crizotinib is 877399-52-5.

More information of Crizotinib 877399-52-5 are:

Synonyms

 PF-02341066;[3-[[(R)-1-(2,6-Dichloro-3-fluorophenyl)ethyl]oxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-yl]amine;3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine;2-Pyridinamine,3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-;

CAS Number

 877399-52-5

Molecular Formula

 C21H22Cl2FN5O

Molecular Weight

 450.343

Density

 1.475 g/cm3

Melting Point

 192 °C

Boiling Point

 599.177 °C at 760 mmHg

Flash Point

 316.171 °C

HS CODE

 29333990

PSA

 77.99000

LogP

 5.94770

Pka

 9.81±0.10(Predicted)

What is Crizotinib (877399-52-5) used for?

Crizotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of selected cases of advanced non-small cell lung cancer. It is a dual ATP competitive inhibitor of tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) and ALK (cellular IC50=20 nM), both of which are important targets for cancer chemotherapy. When crizotinib was tested for selectivity versus other kinases it was found to have enzyme IC50's within 100-fold multiples of c-MET for 13 of the 120 kinases tested. In cellular assays, crizotinib was found to inhibit RON (recepteur d’origine nantais) kinase with a 10-fold selectivity window over c-MET. Altogether, this agent inhibits tumor cell growth.XALKORI?(crizotinib) is a prescription medicine used to treat people with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if XALKORI is safe and effective in children.

InChI:InChI=1/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

Articles related to Crizotinib:

Article

Source

Novel crizotinib–gnrh conjugates revealed the significance of lysosomal trapping in gnRH-based drug delivery systems

Murányi, József,Varga, Attila,Gyulavári, Pál,Pénzes, Kinga,Németh, Csilla E.,Csala, Miklós,Peth?, Lilla,Csámpai, Antal,Halmos, Gábor,Peták, István,Vályi-Nagy, István

, (2019)

Purification method of crizotinib

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Paragraph 0028-0039, (2020/07/15)

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