- Product Name
- CasNo
- MF
- MW
- Content
- Appearance
- Packing
- Apply
- Abemaciclib Mesylate
- 1231930-82-7
- C28H36F2N8O3S
- 602.6990464
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The invention discloses a synthesis meth...
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methanesulfonic acid
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
![6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole](/upload/2024/12/61a9f572-ad32-4137-a432-2484845debe8.png)
6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
LY2835219
| Conditions | Yield |
|---|---|
|
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
at -5 - 0 ℃;
6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole;
In
tetrahydrofuran; toluene;
at 25 - 30 ℃;
methanesulfonic acid;
In
ethanol;
at 50 - 55 ℃;
|
56.65 g |
methanesulfonic acid
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
LY2835219
| Conditions | Yield |
|---|---|
|
In
dichloromethane;
at 20 ℃;
Solvent;
|
methanesulfonic acid
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
5-bromo-2-chloropyridine