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Abemaciclib

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  • Abemaciclib
  • 1231929-97-7
  • C27H32F2N8
  • 506.601
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Reputable supplier selling Abemaciclib 1231929-97-7 with stock

  • Molecular Formula:C27H32F2N8
  • Molecular Weight:506.601
  • Boiling Point:689.3±65.0 °C(Predicted) 
  • PKA:7.69±0.10(Predicted) 
  • PSA：75.00000 
  • Density:1.32±0.1 g/cm3(Predicted) 
  • LogP:4.88570 

1231929-97-7 Relevant articles

A synthesis of abemaciclib utilizing a Leuckart-Wallach reaction

Frederick, Michael O.,Kjell, Douglas P.

, p. 949 - 951 (2015)

A concise total synthesis of CDK 4/6 inh...

Sustainable synthesis of potential antitumor new derivatives of Abemaciclib and Fedratinib via C-N cross coupling reactions using Pd/Cu-free Co-catalyst

Khorsandi, Zahra,Keshavarzipour, Fariba,Varma, Rajender S.,Hajipour, Abdol R.,Sadeghi-Aliabadi, Hojjat

, (2021/11/24)

Herein, chitosan as an inexpensive, abun...

Abecheli intermediate and simple preparation method of Abemaciclib

-

Paragraph 0084-0094, (2019/10/01)

The invention relates to an Abemaciclib ...

CRYSTALLINE POLYMORPHS OF ABEMACICLIB

-

, (2019/06/11)

The present disclosure provides novel po...

PREPARATION METHOD FOR BEMACICLB

-

Paragraph 0057, (2017/11/11)

Disclosed are an intermediate of bemacic...

1231929-97-7 Process route

6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate

N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
Conditions Yield
N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate; With sulfuric acid; sodium methylate; In methanol; N,N-dimethyl-formamide; at 30 - 35 ℃; for 2h;
6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole; at 80 - 85 ℃; for 7h;
90.8%
With sodium hydroxide; In butan-1-ol; at 90 - 100 ℃; Inert atmosphere;
73.1%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
Conditions Yield
With formic acid; trimethyl orthoformate; In acetonitrile; at 80 ℃; for 16h; Reagent/catalyst; Sealed tube;
74%

1231929-97-7 Upstream products

  • 1180132-17-5
    1180132-17-5

    5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine

  • 1231930-42-9
    1231930-42-9

    6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

  • 1231930-37-2
    1231930-37-2

    4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole

  • 5308-25-8
    5308-25-8

    4-ethylpiperazine

1231929-97-7 Downstream products

  • 1231930-82-7
    1231930-82-7

    abemaciclib

  • 1231930-82-7
    1231930-82-7

    LY2835219

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