- Product Name
- CasNo
- MF
- MW
- Content
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- Apply
- Sotorasib
- 2296729-00-3
- 560.603
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Manufacturer supply top purity Sotorasib 2296729-00-3 with GMP standards We supply high quality (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one (CAS 2296729-00-3), in stock, factory directly supply to clients, lower prices, more competitiveness.
(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one is , while it's Molecular Formula is C30H30F2N6O3. Sotorasib (AMG510) is the first KRAS (G12C) inhibitor to enter clinical development. Having shown antitumor activity in clinical trials, AMG 510 represents a potentially transformative therapy.
The CAS number of (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one is 2296729-00-3.
More information of (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one 2296729-00-3 are:
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CAS Number |
2296729-00-3 |
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Molecular Formula |
C30H30F2N6O3 |
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Molecular Weight |
560.603 |
|
Density |
1.36±0.1 g/cm3(Predicted) |
|
Boiling Point |
730.5±70.0 °C(Predicted) |
Sotorasib (AMG510) is a chiral compound and a potent KRAS G12C covalent inhibitor with potential antitumor activity.
Articles related to (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one:
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Article |
Source |
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IMPROVED SYNTHESIS OF KRAS G12C INHIBITOR COMPOUND |
- , (2021/05/21) |
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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors |
Lanman, Brian A.,Allen, Jennifer R.,Allen, John G.,Amegadzie, Albert K.,Ashton, Kate S.,Booker, Shon K.,Chen, Jian Jeffrey,Chen, Ning,Frohn, Michael J.,Goodman, Guy,Kopecky, David J.,Liu, Longbin,Lopez, Patricia,Low, Jonathan D.,Ma, Vu,Minatti, Ana E.,Nguyen, Thomas T.,Nishimura, Nobuko,Pickrell, Alexander J.,Reed, Anthony B.,Shin, Youngsook,Siegmund, Aaron C.,Tamayo, Nuria A.,Tegley, Christopher M.,Walton, Mary C.,Wang, Hui-Ling,Wurz, Ryan P.,Xue, May,Yang, Kevin C.,Achanta, Pragathi,Bartberger, Michael D.,Canon, Jude,Hollis, L. Steven,McCarter, John D.,Mohr, Christopher,Rex, Karen,Saiki, Anne Y.,San Miguel, Tisha,Volak, Laurie P.,Wang, Kevin H.,Whittington, Douglas A.,Zech, Stephan G.,Lipford, J. Russell,Cee, Victor J. , p. 52 - 65 (2020/01/09) |
Hubei Mawer Biological Technology Co., Ltd. is a quality supplier and manufacturer of (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one . You can buy high quality, low price (1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]pyrido[2,3-d]pyrimidin-2(1H)-one 2296729-00-3 here. Contact us.