- Product Name
- CasNo
- MF
- MW
- Content
- Appearance
- Packing
- Apply
- J-147
- 1146963-51-0
- C18H17F3N2O2
- 350.3349896
Manufacturer supply top purity J-147 1146963-51-0 with ISO standards We supply high quality J 147 (CAS 1146963-51-0), in stock, factory directly supply to clients, lower prices, more competitiveness.
J 147 is , while it's Molecular Formula is C18H17F3N2O2. J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer''s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer''s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
The CAS number of J 147 is 1146963-51-0.
More information of J 147 1146963-51-0 are:
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Synonyms |
J 147;J147/J-147;2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide;J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide |
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CAS Number |
1146963-51-0 |
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Molecular Formula |
C18H17F3N2O2 |
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Molecular Weight |
350.3349896 |
|
Density |
1.18±0.1 g/cm3(Predicted) |
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Boiling Point |
412.8±55.0 °C(Predicted) |
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PSA |
41.90000 |
|
LogP |
4.24140 |
|
Pka |
0.80±0.50(Predicted) |
J 147 is a novel neurotrophic drug that serves as a cognitive enhancer and a therapeutic agent for Alzheimer's disease. It is an exceptionally potent, orally active, and broadly neuroprotective compound that has demonstrated the ability to enhance memory in normal animals and prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J 147 are linked to an increase in brain-derived neurotrophic factor (BDNF) levels, the expression of BDNF-responsive proteins, the enhancement of long-term potentiation (LTP), the preservation of synaptic proteins, and the reduction of amyloid plaques.
Articles related to J 147:
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Article |
Source |
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The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease |
Wang, Min,Gao, Mingzhang,Zheng, Qi-Huang , p. 524 - 527 (2013/02/25) |
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