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J-147


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  • J-147
  • 1146963-51-0
  • C18H17F3N2O2
  • 350.3349896
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Manufacturer supply top purity J-147 1146963-51-0 with ISO standards We supply high quality J 147 (CAS 1146963-51-0), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the J 147 ?

J 147 is , while it's Molecular Formula is C18H17F3N2O2. J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer''s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer''s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.

What is the CAS number for J 147 ?

The CAS number of J 147 is 1146963-51-0.

More information of J 147 1146963-51-0 are:

Synonyms

J 147;J147/J-147;2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide;J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

CAS Number

1146963-51-0

Molecular Formula

C18H17F3N2O2

Molecular Weight

350.3349896

Density

1.18±0.1 g/cm3(Predicted)

Boiling Point

412.8±55.0 °C(Predicted)

PSA

41.90000

LogP

4.24140

Pka

0.80±0.50(Predicted)

What is J 147 (1146963-51-0) used for?

J 147 is a novel neurotrophic drug that serves as a cognitive enhancer and a therapeutic agent for Alzheimer's disease. It is an exceptionally potent, orally active, and broadly neuroprotective compound that has demonstrated the ability to enhance memory in normal animals and prevent memory deficits in Alzheimer's disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J 147 are linked to an increase in brain-derived neurotrophic factor (BDNF) levels, the expression of BDNF-responsive proteins, the enhancement of long-term potentiation (LTP), the preservation of synaptic proteins, and the reduction of amyloid plaques.

Articles related to J 147:

Article

Source

The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease

Wang, Min,Gao, Mingzhang,Zheng, Qi-Huang

, p. 524 - 527 (2013/02/25)

How to get the best price on J 147?

Hubei Mawer Biological Technology Co., Ltd. is a quality supplier and manufacturer of J 147 . You can buy high quality, low price J 147 1146963-51-0 here. Contact us.

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