- Product Name
- CasNo
- MF
- MW
- Content
- Appearance
- Packing
- Apply
- Estradiol Valerate
- 979-32-8
- C<sub>23</sub>H<sub>32</sub>O<sub>3</sub>
- 356.505
- Na
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Estradiol valerate is commercially available as an intramuscular injection as the product Delestrogen and is indicated for the treatment of moderate to severe vasomotor symptoms and vulvovaginal atrophy due to menopause, for the treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure, and for the treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). Estradiol valerate is also available in combination with Dienogest as the commercially available product Natazia used for the prevention of pregnancy and for the treatment of heavy menstrual bleeding.
Estradiol valerate is a female hormone (estrogen). It is used to reduce symptoms of menopause which are vaginal dryness, hot flashes, and others. The symptoms of menopause manifest because the body is making less estrogen; with estradiol valerate, these symptoms are brought to the lowest minimum. This medication therapy can also produce enough estrogen in women with ovarian failure, hypogonadism and can be used by men to treat prostate cancer (palliation only).
estradiol divalerate
estradiol 17-valerate
| Conditions | Yield |
|---|---|
|
With
methanol; sodium tetrahydroborate;
at 40 - 45 ℃;
for 2h;
|
74% |
|
With
sodium tetrahydroborate;
In
methanol;
at 40 - 45 ℃;
for 2h;
|
74% |
|
With
sodium hydroxide;
|
|
|
With
methanol; potassium carbonate;
at 20 ℃;
|
3-benzoyloxy-17β-valeryloxy-estra-1,3,5(10)-triene
estradiol 17-valerate
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate;
In
methanol;
|
The CAS number of Estradiol valerate is 979-32-8.
More information of Estradiol valerate 979-32-8 are:
|
CAS Number |
979-32-8 |
|
Density |
1.13 g/cm3 |
|
Melting Point |
144 °C |
|
Boiling Point |
486.2 °C at 760mmHg |
|
Flash Point |
191.1 °C |
|
Vapor Pressure |
4.47E-10mmHg at 25°C |
|
Refractive Index |
1.4700 (estimate) |
|
HS CODE |
29372390 |
|
PSA |
46.53000 |
|
LogP |
5.35030 |
|
Pka |
10.25±0.60(Predicted) |
Synonyms for Estradiol valerate 979-32-8:979-32-8;component of Mal-O-Fem L.A;Repo-Estra;Estra-1,3,5(10)-triene-3,17-diol (17-beta)-, 17-pentanoate;Estraval;Delestrogen;Primogyna;Estroval-10;Estraval PA;Estradiol valerate (VAN);Primogyn-Depot;Delahormone unimatic;Femogen-L.A.;Estra-1,3,5(10)-triene-3,17-diol (17a)-,esters,17-pentanoate;Valerato de estradiol [INN-Spanish];Estradiol 17beta-valerate;Exten strone;Deluteval 2X;Climaval;Estradiol-17-valerate;Gynogen L.A. 40;Oestradiol-17b-valerate;[(8S,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] pentanoate;Progynon-Depot;Femogex;Depo estro med;Estate;Estradiol valerianate;Oestradiol valerate;Progynova;Deladumone (TN);component of Deladumone;Postoval;Ronfase;Atladiol;Estradiol, 17-valerate;Estra-1,3, 5 (10)-triene-3,17-diol (17.beta.)-, 17-pentanoate;Estradiol valerate [USAN:INN:JAN];
The chemical formula of Estradiol valerate is C23H32O3 which containing 23 Carbon atoms,32 Hydrogen atoms and 3 Oxygen atoms,and the molecular weight of Estradiol valerate is 356.505.
Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. In women, it is used in hormone therapy for menopausal symptoms and low estrogen levels, hormone therapy for transgender women, and in hormonal birth control. It is also used in the treatment of prostate cancer in men. The medication is taken by mouth or by injection into muscle or fat once every 1 to 4 weeks.
InChI:InChI=1/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18?,19?,20?,21-,23-/m0/s1
Relevant articles related to Estradiol valerate:
|
Article |
Source |
|
IMPROVED PROCESS FOR PREPARATION OF ESTRADIOL VALERATE AND A NOVEL CRYSTALLINE FORM A OF ESTRADIOL DIVALERATE |
- Page/Page column 10, (2012/05/20) |
|
Preparation of some estriol esters. |
TSUNEDA,YAMADA,YASUDA,MORI , p. 510 - 514 (2007/10/13) |
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