Polymyxin B Sulfate


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  • Polymyxin B Sulfate
  • 1405-20-5
  • C<sub>56</sub>H<sub>98</sub>N<sub>16</sub>O<sub>13</sub><sup>.</sup>H<sub>2</sub>SO<sub>4</sub>
  • 1301.56
  • White crystalline powder
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What is the Polymyxin B sulfate ?

Polymyxin B sulfate is White crystalline powder, while it's Molecular Formula is C56H98N16O13.H2SO4. Polymyxin B sulfate is used as topical antibiotic agent, often used in combination with neomycin; products include ointments, creams, eye, and ear drops.

What is the CAS number for Polymyxin B sulfate ?

The CAS number of Polymyxin B sulfate is 1405-20-5.

More information of Polymyxin B sulfate 1405-20-5 are:

Synonyms

Campho-Phenique Antibiotic Plus Pain Relief Ointment;Ophthocort;Neosporin Plus;Dexacidin;Neobacimyx (Veterinary);Polymixin B sulfate (JP14);Aerosporin (TN);Poly-Pred;Drotic;Pediotic Suspension;Statrol;2-[(4-amino-2-formamido-butanoyl)amino]-N-[3-amino-1-[[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(2-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]-4-hydroxy-butanamide; sulfuric acid;Neosporin;Aerosporin;Chloromyxin;Otocort;Mastimyxin;

CAS Number

1405-20-5

Molecular Formula

C56H98N16O13.H2SO4

Molecular Weight

1301.56

Melting Point

217-220°C (dec.)

Boiling Point

1651ºC at 760 mmHg

Flash Point

952.3ºC

HS CODE

2941 90 00

PSA

573.64000

LogP

2.54990

Pka

pKa 8.9 (Uncertain)

What is Polymyxin B sulfate (1405-20-5) used for?

The polymyxins are cationic peptides originally isolated from B. polymyxa. They bind and kill Gram-negative bacteria. The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B (sulfate) is a mixture of at least four closely related components, polymyxin B1 to B4, with polymyxin B1 and B2 being the two major components. Polymyxin B (sulfate) has rapid in vitro bactericidal activity against major multidrug-resistant Gram-negative bacteria, such as P. aeruginosa, A. baumannii, and K. pneumoniae.

InChI:InChI=1/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

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