- Product Name
- CasNo
- MF
- MW
- Content
- Appearance
- Packing
- Apply
- Tamoxifen Citrate
- 54965-24-1
- C<sub>26</sub>H<sub>29</sub>NO<sup>.</sup>C<sub>6</sub>H<sub>8</sub>O<sub>7</sub>
- 563.648
- white to off-white powder
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Tamoxifen Citrate is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4.
1-(4-(2-(dimethylamino)ethoxy)phenyl)-1,2-diphenylbutan-1-ol
citric acid
tamoxifen citrate
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethylamine citrate
| Conditions | Yield |
|---|---|
|
1-(4-(2-(dimethylamino)ethoxy)phenyl)-1,2-diphenylbutan-1-ol;
With
hydrogenchloride;
In
water; isopropyl alcohol;
for 5h;
Reflux;
citric acid;
In
acetone;
at -5 - 10 ℃;
for 10h;
|
7.5 g |
1-(4-(2-(dimethylamino)ethoxy)phenyl)-1,2-diphenylbutan-1-ol
citric acid
tamoxifen citrate
(Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethylamine citrate
| Conditions | Yield |
|---|---|
|
1-(4-(2-(dimethylamino)ethoxy)phenyl)-1,2-diphenylbutan-1-ol;
With
hydrogenchloride;
In
water; isopropyl alcohol;
for 5h;
Reflux;
citric acid;
In
acetone;
at -5 - 10 ℃;
for 10h;
|
7.5 g |
The CAS number of Tamoxifen citrate is 54965-24-1.
More information of Tamoxifen citrate 54965-24-1 are:
|
CAS Number |
54965-24-1 |
|
Melting Point |
140-144 °C |
|
Boiling Point |
665.9 °C at 760 mmHg |
|
Flash Point |
356.5 °C |
|
HS CODE |
29225090 |
|
PSA |
144.60000 |
|
LogP |
4.74760 |
Synonyms for Tamoxifen citrate 54965-24-1:Farmifeno;Oncomox;Tamoxifen citrate (JAN/USP);Tafoxen;Kessar;Tamoxasta;Tamoxifenum [INN-Latin];Nolvadex (TN);Soltamox;Noxitem;Oncotam;Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Crisafeno;Nourytan;Tamoplex;Tamofen;ICI 46474;Tamax;Tamoxifene [INN-French];Tamoxen;Nolvadex;Ethanamine,2-[4-[(1Z)-1,2-diphenyl-1- butenyl]phenoxy]-N,N-dimethyl-,2-hydroxy- 1,2,3-propanetricarboxylate (1:1);2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethyl-ethanamine; 2-hydroxypropane-1,2,3-tricarboxylic acid;Valodex;Ethanamine, 2-[4- (1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-, (Z)-, 2-hydroxy-1,2,3-propane-tricarboxylate (1:1);
The chemical formula of Tamoxifen citrate is C26H29NO.C6H8O7 which containing 32 Carbon atoms,37 Hydrogen atoms,1 Nitrogen atoms and 7 Oxygen atoms,and the molecular weight of Tamoxifen citrate is 563.648.
Tamoxifen citrate (54965-24-1) is an estrogen receptor antagonist/partial agonist. Induces oxidative stress and apoptosis in estrogen receptor-negative cancer cell lines.1 Displays neuroprotective effects in permanent focal ischemia.2 Inhibits PKC.3 Potent agonist at GPR30 (membrane estrogen receptor).4 Clinically useful breast cancer agent.5
InChI:InChI=1/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b26-25-;
Relevant articles related to Tamoxifen citrate:
|
Article |
Source |
|
A tamoxifen E isomer preparation method |
- Paragraph 0055-0059, (2017/03/08) |
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