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1.What is the Budesonide ?

Budesonide is a synthetic corticosteroid having a potent glucocorticoid and weak mineralocorticoid activity. In standard in vitro and animal models, budesonide has an approximately 200-fold higher affinity for the glucocorticoid receptor and a 1000-fold higher topical antiinflammatory potency than cortisol.

Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor with an EC50 value of 12.4 nM. Like other glucocorticoids, budesonide reduces inflammation and has utility in inflammatory diseases, like asthma and inflammatory bowel disease. Also like other glucocorticoids, budesonide may be abused by athletes.[Cayman Chemical]

2.What is the CAS number for Budesonide ?

The CAS number of Budesonide is 51333-22-3.

More information of Budesonide 51333-22-3 are:

3.What are another words for Budesonide ?

Synonyms for Budesonide 51333-22-3:Budeson;Respules;16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione;Entocort;Pregna-1,4-diene-3,20-dione,16,17- [butylidenebis(oxy)]-11,21-dihydroxy-,(11a,- 16R)-;Rhinocort;Budesonide (11beta,16alpha);Micronyl;Preferid;(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde;(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione;Cortivent;Prestwick_840;Rhinocort alpha;

4.What is the molecular formula of Budesonide?

The chemical formula of  Budesonide is C25H34O6 which containing 25 Carbon atoms,34 Hydrogen atoms and 6 Oxygen atoms,and the molecular weight of  Budesonide is 430.59.

5.What is Budesonide (51333-22-3) used for?

Budesonide is composed of a 1:1 mixture of epimers of the 16,17-butylacetal, creating a chiral center. The 22R-epimer binds to the GR with higher affinity than does the 22S-epimer (Table 33.5). The butyl acetal chain provided the highest potency for the homologous acetal chains. Its rate of topical uptake into epithelial tissue is more than 100 times faster than that for hydrocortisone and dexamethasone. Approximately 85% of the IV administered dose of budesonide undergoes extensive first-pass hepatic metabolism by CYP3A4 to its primary metabolites, 6β-hydroxybudesonide and 16α-hydroxyprednisolone, which have approximately 1/100 the potency of budesonide. This is an important inactivation step in limiting budesonide's systemic effect on adrenal suppression.

InChI:InChI=1/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17?,18-,20?,21?,22?,23-,24-,25?/m0/s1

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